Cannabis and Parkinson’s Disease
Parkinson’s disease, likewise known as PD, is the 2nd most typical neurodegenerative disorder. In this video clip we will specify Parkinson’s illness and also cannabis, explain exactly how marijuana can assist with PD, and medical professional viewpoints on recommending cannabis.
This video was created by Demystifying Medicine trainees Simran Matharu, Mahek Minhas and also Micaela McNulty in partnership with the McMaster Demystifying Medicine Program
Copyright McMaster University 2021
For more details see:
https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm
Time Stamps:
Introduction/What is Parkinson’s Disease? → 00:00 – 01:23
What is Cannabis? → 01:24 – 02:34
How Can Cannabis Help With Parkinson’s? → 02:35 – 05:09
Doctor Perspectives → 05:10 – 07:19
Final thought → 07:20 – 07:52
Referrals:
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Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009 ). The endocannabinoid system as a target for the treatment of cannabis reliance. Neuropharmacology, 56, 235– 243.
de Lau, L. M., & Breteler, M. M. (2006 ). Public health of Parkinson’s disease. The Lancet Neurology, 5( 6 ), 525– 535.
Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020 ). Beliefs and also mindsets of graduate gerontology trainees regarding medical marijuana use for Alzheimer’s and also Parkinson’s illness. Corresponding Therapies in Medicine, 52, 102418.
Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019 ). Health expert ideas, understanding, and concerns surrounding medical cannabis– An organized evaluation. PLOS ONE, 14( 5 ), e0216556.
Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007 ). Ten-year follow-up of Parkinson’s disease people randomized to preliminary therapy with ropinirole or levodopa. Motion disorders: main journal of the Movement Disorder Society, 22( 16 ), 2409– 2417.
Jankovic, J. (2008 ). Parkinson’s disease: Clinical attributes and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79( 4 ), 368– 376.
Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011 ). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioral results as well as alters THC pharmacokinetics during persistent as well as intense treatment in adolescent rats. Psychopharmacology, 218( 2 ), 443– 457.
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Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018 ). Occurrence of Parkinson’s illness throughout North America. Npj Parkinson’s Disease, 4( 1 ), 21.
Nutt J. G. (2000 ). Response to L-dopa in PD: the lengthy and also the except it. Neurology, 54( 10 ), 1884– 1885. https://doi.org/10.1212/wnl.54.10.1884
Oeckl, P., Hengerer, B., & Ferger, B. (2014 ). G-protein coupled receptor 6 deficiency changes striatal dopamine as well as cAMP focus and reduces dyskinesia in a mouse model of Parkinson’s disease. Experimental neurology, 257, 1– 9. https://doi.org/10.1016/j.expneurol.2014.04.010
Extreme Spasticity. (2020 ). https://lioresal.com/severe-spasticity/.
Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004 ). Study on marijuana use in Parkinson’s condition: subjective renovation of motor symptoms. Activity disorders: main journal of the Movement Disorder Society, 19( 9 ), 1102– 1106. https://doi.org/10.1002/mds.20111
Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017 ). Measurable Determination of Cannabinoids in Cannabis as well as Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography as well as Diode Array/Mass Spectrometric Detection.
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